Myrox এর ব্যবহার, ডোজ, পার্শ্বপ্রতিক্রিয়া

Description

Myrox is a preparation of ambroxol hydrochloride, which is a metabolite of bromhexine. It possesses greater mucolytic and expectorant effects than bromhexine. Ambroxol directly acts on the mucus-secreting cells. It increases the content of mucus secretion and reduces the viscosity of mucus by splitting the mucoproteins and mucopolysaccharide fibres. Thus, it liquefies the viscid mucus. As ambroxol does not suppress the body’s natural cough response, it facilitates the expulsion of mucus (expectoration) and eases breathing. Ambroxol maximizes the efficacy of antibiotics against pathogens involved in coughing and infection. It increases areal porosity, decreases biofilm thickness, and decreases the average diffusion distance. In addition to its anti-inflammatory and antioxidant properties, ambroxol stimulates the production of surfactant phospholipids by alveolar cells, which reduces inflammation and shields the airways. This helps COPD patients’ airways remain open and maximizes the effectiveness of antibiotics by increasing their penetration into bacterial cells. The preparation’s high tolerability allows for long-term use.

Indications

Myrox® is indicated for the treatment of:
  • Productive cough
  • Acute and chronic inflammatory disorders of upper and lower respiratory tracts associated with viscid mucus, including acute and chronic bronchitis
  • Inflammatory disease of rhinopharyngeal tract (laryngitis, pharyngitis, sinusitis and rhinitis) associated with viscid mucus
  • Asthmatic bronchitis, bronchial asthma with thick expectoration
  • Bronchiectasis
  • Chronic pneumonia

Dosage and administration

Age                                                                                       Myrox® SR capsule

Adults & Children over 12 years old                                  1 capsule daily

                                                                                               Myrox Paediatric Drops

Children 0-6 months                                                           0.5 ml, 2 times daily

Children 6-12 months                                                         1 ml, 2 times daily

Children 12-24 months                                                      1.25 ml, 2 times daily

                                                                                              Myrox® Syrup

Children 2–6 years of age 1 teaspoonful (5 ml) 2 to 3 times daily

Children 6-12 years                                                          ½ teaspoonful (2.5 ml) 2 to 3 times daily

Adult                                                                                    2 teaspoonfuls (10 ml) 3 times daily

 

Side effects

The common side effects of ambroxol are nausea, vomiting, and gastrointestinal troubles (epigastric pain, gastric fullness).

Use in pregnancy and lactation

Teratogenic and fetal toxicity studies have shown no harmful effects of ambroxol. Since its safety during lactation has not been demonstrated, it is advised to avoid using it during pregnancy, particularly in the first trimester.

Contraindications

Contraindicated in patients with a known history of hypersensitivity to ambroxol or bromhexine.

Precautions

Ambroxol should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic, renal, or bronchomotor function insufficiency should take it with caution.

Drug interactions

Ambroxol should not be taken with antitussives such as codeine at the same time because it has liquefied phlegm. Ambroxol does not interact with diuretics, corticosteroids, bronchodilators, or cardioactive glycosides.

Pharmaceutical precautions

Store in a cool (below 30°C) and dry place. Protect from light. Keep away from the reach of children.

Presentation

Myrox Pediatric Drops: Each mL contains Ambroxol Hydrochloride BP 6 mg. Myrox® Syrup: Each 5 ml contains ambroxol hydrochloride (BP 15 mg).

Myrox SR Capsule: Each capsule contains Ambroxol Hydrochloride BP 75 mg sustained-release pellets.

Package quantities

Myrox Syrup: comes in a 100-ml bottle;

Myrox Pediatric: Drops come in a 15-ml vial with a food-grade dropper; and

Myrox SR: Capsules are packaged in a blister that contains 30 capsules.

 

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